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typical antipsychotics  (Vieweg GmbH)

 
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    Vieweg GmbH typical antipsychotics
    Typical Antipsychotics, supplied by Vieweg GmbH, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/typical+antipsychotics/antipsychotic+drugs/pm21301815-33-17-19
    Average 90 stars, based on 1 article reviews
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    other:

    Article Title: Sex difference in QTc prolongation in chronic institutionalized patients with schizophrenia on long-term treatment with typical and atypical antipsychotics.
    Article Snippet: Objective The rate-corrected electrocardiographic QT (QTc) interval may significantly increase in patients with schizophrenia taking antipsychotics.. The objective of this naturalistic study was to assess the prevalence of prolonged QTc interval in a large population of inpatients with chronic schizophrenia and to explore QTc relationship with demographic variables and prescribed treatments.. Materials and methods Electrocardiograms were obtained from ageand sex-matched 456 controls and 1,006 inpatients with schizophrenia (male/female=689/317) taking antipsychotics.



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    Fig. 2. Mean time in seconds in the bar test measured using the instrument (Inst) (graphs A, C, E), instrument plus stopwatch (SW + Inst) (graph E, solid line), or in the <t>CLP</t> test measured with a stopwatch (graphs B, D, and F). Graph A, <t>haloperidol</t> bar instrument, AED50 = 0.29 mg/kg. Graph B, haloperidol CLP, AED50 = 0.38 mg/kg. Graph C, clozapine bar instrument, no significant catalepsy. Graph D, clozapine CLP, significant catalepsy at 40 mg/kg. Graph E, olanzapine stopwatch + instrument (SW + Inst.), significant catalepsy at 40 mg/kg. Graph E, Inst. only, gripping problems prevented accurate detection of time on the bar. Dashed line shown only to illustrate problem. Graph F, olanzapine CLP, significant catalepsy at 40 mg/kg. n = 7 rats/dose. Compared to vehicle, **, ***, and **** indicate p b 0.01, 0.001, and 0.0001 respectively.
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    Fig. 2. Mean time in seconds in the bar test measured using the instrument (Inst) (graphs A, C, E), instrument plus stopwatch (SW + Inst) (graph E, solid line), or in the <t>CLP</t> test measured with a stopwatch (graphs B, D, and F). Graph A, <t>haloperidol</t> bar instrument, AED50 = 0.29 mg/kg. Graph B, haloperidol CLP, AED50 = 0.38 mg/kg. Graph C, clozapine bar instrument, no significant catalepsy. Graph D, clozapine CLP, significant catalepsy at 40 mg/kg. Graph E, olanzapine stopwatch + instrument (SW + Inst.), significant catalepsy at 40 mg/kg. Graph E, Inst. only, gripping problems prevented accurate detection of time on the bar. Dashed line shown only to illustrate problem. Graph F, olanzapine CLP, significant catalepsy at 40 mg/kg. n = 7 rats/dose. Compared to vehicle, **, ***, and **** indicate p b 0.01, 0.001, and 0.0001 respectively.
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    Fig. 2. Mean time in seconds in the bar test measured using the instrument (Inst) (graphs A, C, E), instrument plus stopwatch (SW + Inst) (graph E, solid line), or in the <t>CLP</t> test measured with a stopwatch (graphs B, D, and F). Graph A, <t>haloperidol</t> bar instrument, AED50 = 0.29 mg/kg. Graph B, haloperidol CLP, AED50 = 0.38 mg/kg. Graph C, clozapine bar instrument, no significant catalepsy. Graph D, clozapine CLP, significant catalepsy at 40 mg/kg. Graph E, olanzapine stopwatch + instrument (SW + Inst.), significant catalepsy at 40 mg/kg. Graph E, Inst. only, gripping problems prevented accurate detection of time on the bar. Dashed line shown only to illustrate problem. Graph F, olanzapine CLP, significant catalepsy at 40 mg/kg. n = 7 rats/dose. Compared to vehicle, **, ***, and **** indicate p b 0.01, 0.001, and 0.0001 respectively.
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    Fig. 2. Mean time in seconds in the bar test measured using the instrument (Inst) (graphs A, C, E), instrument plus stopwatch (SW + Inst) (graph E, solid line), or in the <t>CLP</t> test measured with a stopwatch (graphs B, D, and F). Graph A, <t>haloperidol</t> bar instrument, AED50 = 0.29 mg/kg. Graph B, haloperidol CLP, AED50 = 0.38 mg/kg. Graph C, clozapine bar instrument, no significant catalepsy. Graph D, clozapine CLP, significant catalepsy at 40 mg/kg. Graph E, olanzapine stopwatch + instrument (SW + Inst.), significant catalepsy at 40 mg/kg. Graph E, Inst. only, gripping problems prevented accurate detection of time on the bar. Dashed line shown only to illustrate problem. Graph F, olanzapine CLP, significant catalepsy at 40 mg/kg. n = 7 rats/dose. Compared to vehicle, **, ***, and **** indicate p b 0.01, 0.001, and 0.0001 respectively.
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    Fig. 2. Mean time in seconds in the bar test measured using the instrument (Inst) (graphs A, C, E), instrument plus stopwatch (SW + Inst) (graph E, solid line), or in the <t>CLP</t> test measured with a stopwatch (graphs B, D, and F). Graph A, <t>haloperidol</t> bar instrument, AED50 = 0.29 mg/kg. Graph B, haloperidol CLP, AED50 = 0.38 mg/kg. Graph C, clozapine bar instrument, no significant catalepsy. Graph D, clozapine CLP, significant catalepsy at 40 mg/kg. Graph E, olanzapine stopwatch + instrument (SW + Inst.), significant catalepsy at 40 mg/kg. Graph E, Inst. only, gripping problems prevented accurate detection of time on the bar. Dashed line shown only to illustrate problem. Graph F, olanzapine CLP, significant catalepsy at 40 mg/kg. n = 7 rats/dose. Compared to vehicle, **, ***, and **** indicate p b 0.01, 0.001, and 0.0001 respectively.
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    Fig. 2. Mean time in seconds in the bar test measured using the instrument (Inst) (graphs A, C, E), instrument plus stopwatch (SW + Inst) (graph E, solid line), or in the <t>CLP</t> test measured with a stopwatch (graphs B, D, and F). Graph A, <t>haloperidol</t> bar instrument, AED50 = 0.29 mg/kg. Graph B, haloperidol CLP, AED50 = 0.38 mg/kg. Graph C, clozapine bar instrument, no significant catalepsy. Graph D, clozapine CLP, significant catalepsy at 40 mg/kg. Graph E, olanzapine stopwatch + instrument (SW + Inst.), significant catalepsy at 40 mg/kg. Graph E, Inst. only, gripping problems prevented accurate detection of time on the bar. Dashed line shown only to illustrate problem. Graph F, olanzapine CLP, significant catalepsy at 40 mg/kg. n = 7 rats/dose. Compared to vehicle, **, ***, and **** indicate p b 0.01, 0.001, and 0.0001 respectively.
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    Fig. 2. Mean time in seconds in the bar test measured using the instrument (Inst) (graphs A, C, E), instrument plus stopwatch (SW + Inst) (graph E, solid line), or in the <t>CLP</t> test measured with a stopwatch (graphs B, D, and F). Graph A, <t>haloperidol</t> bar instrument, AED50 = 0.29 mg/kg. Graph B, haloperidol CLP, AED50 = 0.38 mg/kg. Graph C, clozapine bar instrument, no significant catalepsy. Graph D, clozapine CLP, significant catalepsy at 40 mg/kg. Graph E, olanzapine stopwatch + instrument (SW + Inst.), significant catalepsy at 40 mg/kg. Graph E, Inst. only, gripping problems prevented accurate detection of time on the bar. Dashed line shown only to illustrate problem. Graph F, olanzapine CLP, significant catalepsy at 40 mg/kg. n = 7 rats/dose. Compared to vehicle, **, ***, and **** indicate p b 0.01, 0.001, and 0.0001 respectively.
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    Fig. 2. Mean time in seconds in the bar test measured using the instrument (Inst) (graphs A, C, E), instrument plus stopwatch (SW + Inst) (graph E, solid line), or in the <t>CLP</t> test measured with a stopwatch (graphs B, D, and F). Graph A, <t>haloperidol</t> bar instrument, AED50 = 0.29 mg/kg. Graph B, haloperidol CLP, AED50 = 0.38 mg/kg. Graph C, clozapine bar instrument, no significant catalepsy. Graph D, clozapine CLP, significant catalepsy at 40 mg/kg. Graph E, olanzapine stopwatch + instrument (SW + Inst.), significant catalepsy at 40 mg/kg. Graph E, Inst. only, gripping problems prevented accurate detection of time on the bar. Dashed line shown only to illustrate problem. Graph F, olanzapine CLP, significant catalepsy at 40 mg/kg. n = 7 rats/dose. Compared to vehicle, **, ***, and **** indicate p b 0.01, 0.001, and 0.0001 respectively.
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    Fig. 2. Mean time in seconds in the bar test measured using the instrument (Inst) (graphs A, C, E), instrument plus stopwatch (SW + Inst) (graph E, solid line), or in the <t>CLP</t> test measured with a stopwatch (graphs B, D, and F). Graph A, <t>haloperidol</t> bar instrument, AED50 = 0.29 mg/kg. Graph B, haloperidol CLP, AED50 = 0.38 mg/kg. Graph C, clozapine bar instrument, no significant catalepsy. Graph D, clozapine CLP, significant catalepsy at 40 mg/kg. Graph E, olanzapine stopwatch + instrument (SW + Inst.), significant catalepsy at 40 mg/kg. Graph E, Inst. only, gripping problems prevented accurate detection of time on the bar. Dashed line shown only to illustrate problem. Graph F, olanzapine CLP, significant catalepsy at 40 mg/kg. n = 7 rats/dose. Compared to vehicle, **, ***, and **** indicate p b 0.01, 0.001, and 0.0001 respectively.
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    other typical antipsychotics  (Adis International Limited)
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    Fig. 2. Mean time in seconds in the bar test measured using the instrument (Inst) (graphs A, C, E), instrument plus stopwatch (SW + Inst) (graph E, solid line), or in the <t>CLP</t> test measured with a stopwatch (graphs B, D, and F). Graph A, <t>haloperidol</t> bar instrument, AED50 = 0.29 mg/kg. Graph B, haloperidol CLP, AED50 = 0.38 mg/kg. Graph C, clozapine bar instrument, no significant catalepsy. Graph D, clozapine CLP, significant catalepsy at 40 mg/kg. Graph E, olanzapine stopwatch + instrument (SW + Inst.), significant catalepsy at 40 mg/kg. Graph E, Inst. only, gripping problems prevented accurate detection of time on the bar. Dashed line shown only to illustrate problem. Graph F, olanzapine CLP, significant catalepsy at 40 mg/kg. n = 7 rats/dose. Compared to vehicle, **, ***, and **** indicate p b 0.01, 0.001, and 0.0001 respectively.
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    Image Search Results


    Fig. 2. Mean time in seconds in the bar test measured using the instrument (Inst) (graphs A, C, E), instrument plus stopwatch (SW + Inst) (graph E, solid line), or in the CLP test measured with a stopwatch (graphs B, D, and F). Graph A, haloperidol bar instrument, AED50 = 0.29 mg/kg. Graph B, haloperidol CLP, AED50 = 0.38 mg/kg. Graph C, clozapine bar instrument, no significant catalepsy. Graph D, clozapine CLP, significant catalepsy at 40 mg/kg. Graph E, olanzapine stopwatch + instrument (SW + Inst.), significant catalepsy at 40 mg/kg. Graph E, Inst. only, gripping problems prevented accurate detection of time on the bar. Dashed line shown only to illustrate problem. Graph F, olanzapine CLP, significant catalepsy at 40 mg/kg. n = 7 rats/dose. Compared to vehicle, **, ***, and **** indicate p b 0.01, 0.001, and 0.0001 respectively.

    Journal: Pharmacology, biochemistry, and behavior

    Article Title: Evaluation of the potential of antipsychotic agents to induce catalepsy in rats: assessment of a new, commercially available, semi-automated instrument.

    doi: 10.1016/j.pbb.2014.02.013

    Figure Lengend Snippet: Fig. 2. Mean time in seconds in the bar test measured using the instrument (Inst) (graphs A, C, E), instrument plus stopwatch (SW + Inst) (graph E, solid line), or in the CLP test measured with a stopwatch (graphs B, D, and F). Graph A, haloperidol bar instrument, AED50 = 0.29 mg/kg. Graph B, haloperidol CLP, AED50 = 0.38 mg/kg. Graph C, clozapine bar instrument, no significant catalepsy. Graph D, clozapine CLP, significant catalepsy at 40 mg/kg. Graph E, olanzapine stopwatch + instrument (SW + Inst.), significant catalepsy at 40 mg/kg. Graph E, Inst. only, gripping problems prevented accurate detection of time on the bar. Dashed line shown only to illustrate problem. Graph F, olanzapine CLP, significant catalepsy at 40 mg/kg. n = 7 rats/dose. Compared to vehicle, **, ***, and **** indicate p b 0.01, 0.001, and 0.0001 respectively.

    Article Snippet: Contents lists available at ScienceDirect Pharmacology, Biochemistry and Behavior j ourna l homepage: www.e lsev ie r .com/ locate /pharmbiochembeh Evaluation of the potential of antipsychotic agents to induce catalepsy in rats: Assessment of a new, commercially available, semi-automated instrument Barbara Bricker, Dinithia Sampson, Seth Y. Ablordeppey Division of Basic Pharmaceutical Sciences, Florida A&M University, College of Pharmacy and Pharmaceutical Sciences, Tallahassee, FL 32307, USA http://dx.doi.org/10.1016/j.pbb.2014.02.013 0091-3057/Published by Elsevier Inc. a b s t r a c t a r t i c l e i n f o Article history: Received 12 August 2013 Received in revised form 7 January 2014 Accepted 16 February 2014 Available online 21 February 2014 Keywords: Catalepsy instrument Bar test for catalepsy Extrapyramidal side effect (EPS) Crossed-leg position (CLP) test Typical antipsychotics Atypical antipsychotics Haloperidol induced catalepsy was determined using the classic bar test and a new MED Associates Catalepsy Test Chamber instrument.

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